CD274 and neoplasm: Given that resistance to immunotherapy in TNBC can be explained by the contribution of several immune-related pathways and their cross-talk to form an effective anti-tumor immune response, the potential integration of proteomics-derived IHC biomarkers concurrently with PD1/PDL1 panels could be leveraged for better matching of TNBC patients to immune checkpoint blockade until TNBC proteomic classifiers can be adapted into clinical practice.