Drp1 knockdown reduced the expression of EZH2 in the cerebral cortex of CKD mice, which could be rescued by manipulation with AAV2 expressing EZH2; whereas, HIF-1ɑ protein level remained unaffected by restoration of EZH2 in the presence of Drp1 (Fig. 6A, B). Here, HIF1A is linked to chronic kidney disease.