However, there were no significant differences in the percentages of Th1, Th2, Th17, CD4+ TNFα+ , CD4+ TGFβ+ cells (Fig. 3L), Treg/Th17 ratio, and Th1/Th2 ratio between positive pathogen-ITP and negative pathogen-ITP patients. Here, TNF is linked to autoimmune thrombocytopenic purpura.