CD4 T cell and CD8 T cell, including Th1, Th2, Th17, Tregs, and GnBCD8 T cells have been reported to have changes in quantity or function in autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and ITP [6, 7, 22, 30, 31]. This evidence concerns the gene CD4 and rheumatoid arthritis.