In addition, current study showed that there were no significant differences in Th1, Th2, Th17, Th1/Th2 ratio, Treg/Th17 ratio, CD8 T cell, and most of the plasma lipid metabolites between positive pathogen-ITP and negative pathogen-ITP patients, indicating that the presence of microorganisms is not a driver to ITP pathogenesis and the pathogenesis of positive pathogen-ITP in present study are in accordance with primary ITP. Here, CD8A is linked to autoimmune thrombocytopenic purpura.