NEAT1 and rheumatoid arthritis: To test whether NEAT1 directly binds to miR-338-3p, FLSs from RA patients were incubated with wild-type NEAT1 (WT-NEAT1) or binding site mutant NEAT1 (Mut-NEAT1) co-transfected with a luciferase vector containing control miRNA or miR-338-3p.