NEAT1 and rheumatoid arthritis: As expected, NEAT1 expression was significantly elevated in human FLSs-RA compared to normal FLSs (Fig. 1A) To assess the cellular function of NEAT1 in FLSs-RA, we tested apoptosis and nutrient metabolism; FLSs-RA deficient in NEAT1 showed a significant increase in apoptosis induction substance, H2O2 500 μM and 1000 μM, for 8 h.