For example, blockage of TGFβ-mediated SMAD3 phosphorylation prevented bleomycin (BLM)-induced pulmonary fibrosis (PF); however, TGFβ or SMAD3 deletion caused abnormal lung organogenesis and systemic inflammation in mouse models [12, 13]. The gene discussed is TGFB1; the disease is pulmonary fibrosis.