In general, medications for RA includes anti-inflammatory drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids, and relieves symptoms drugs, such as methotrexate, leflunomide, hydroxychloroquine, etc. Previously, Wang et al. reported that TXNDC5 is detected in synovial tissues and blood from RA patients [116]. Here, TXNDC5 is linked to rheumatoid arthritis.