IMPACT and cancer: Still it is interesting and needs further investigations that the in the reported family duplication region in 18q11.1q11.2 encompasses 25 genes as ROCK1, GREB1L, ABHD3, ANKRD29, AQP4, CABLES1, CABRY, CHST9, CTAGE1, ESCO1, GATA6, IMPACT, KCTD1, LAMA3, MIB1, NPC1, OSBPL1A, PBBP8, RIOK3, RP11, SNRPD1, SS18, TAF4B, TMEM241 and TTC39C. In these 25 genes, genetic alterations of ROCK1, ABHD3, ANKRD29, CABLES1 and CTAGE1, including deletion, methylation, and point mutations, are directly involved in the development of human cancer and other diseases [11–13].