In a recent meta-analysis of 9 studies including 26,442 participants of general population, those in the top third of OPG concentration had higher combined risk ratio for CVD (1.83), CAD (1.72), and stroke (1.58), compared to individuals at the bottom third of OPG concentration, implicating its predictive power [16]. Here, TNFRSF11B is linked to coronary artery disorder.