TNFRSF11B and peripheral arterial disease: In details, a study enrolling T2DM patients without known CVD, demonstrated significantly increased OPG levels in patients with carotid and peripheral arterial disease compared to controls, but this association remained significant only for carotid disease after adjustment for age, glycosylated hemoglobin (HbA1c) and urine albumin-to-creatinine ratio [8].