In a recent meta-analysis of 9 studies including 26,442 participants of general population, those in the top third of OPG concentration had higher combined risk ratio for CVD (1.83), CAD (1.72), and stroke (1.58), compared to individuals at the bottom third of OPG concentration, implicating its predictive power [16]. This evidence concerns the gene TNFRSF11B and stroke disorder.