The results showed that smoking history (OR = 168.56 95%CI 5.03–5643.91, P < 0.01), IL-6 (OR = 25.28 95%CI 1.9–335.89, P = 0.01), CRP (OR = 12.85 95%CI 1.21–137.02, P = 0.03), CD8 + T lymphocyte count (OR = 74.68 95%CI 4.09–1364.72, P < 0.01), SP-A (OR = 46.92 95%CI 2.54–867.77, P = 0.01) and KL-6 (OR = 123.44 95%CI 6.3–2420.57, P < 0.01) were independent influence factors of CIP. Here, MUC1 is linked to hereditary sensory and autonomic neuropathy.