Since those with polymorphisms near the MC4R gene are more prone to suffer from obesity [41–43], obesity contributes directly to incidence of cardiovascular risk factors [44, 45], and since there is purportedly a positive relationship between adherence to ND and anthropometric measurements in recent studies, we sought to assess the interaction between MND and MC4R polymorphism on cardiovascular risk factors among overweight and obese Iranian women. Here, MC4R is linked to obesity due to melanocortin 4 receptor deficiency.