This is evidenced by modest radiological responses to single agent temozolomide (TMZ) or dacarbazine in MGMT methylated or protein negative tumours that do not characteristically respond when not biomarker selected (e.g. oesophageal or colorectal cancer (CRC) (9.4% ORR in oesophageal cancer) [26, 27]. Here, MGMT is linked to neoplasm.