In diffuse large B-cell lymphoma cells (Nie et al. 2019) and colon adenocarcinoma cells (Tohme et al. 2016), NETs could exert pro-tumorigenic effects by activating TLR9 and its downstream signaling through pathways such as NF-kB and MAPK. The gene discussed is TLR9; the disease is colon adenocarcinoma.