Strikingly, compared with the vehicle control, PF543 treatment substantially reduced CD11b+F4/80+CD206+MHC class II- tumor-associated macrophages (TAMs) and Gr-1+CD11b+ MDSCs, but did not contribute to the tumor infiltration of CD11b+F4/80+MHC class II+CD206- cell subsets (Supplementary Fig. 3j–m). The gene discussed is ITGAM; the disease is neoplasm.