In the current study, we focused on two aspects, (1) the potential prognostic value of urinary PSA and (2) determine the clinical utility of urinary marker panels consisted of previously identified urinary glycopeptides and urinary PSA in various combinations for distinguishing aggressive PCa (GG2 and above) from non-aggressive (GG1) since GG2 and GG3 were not included in our previous work. This evidence concerns the gene KLK3 and posterior cortical atrophy.