PITX2 and neoplasm: In a subsample of patients whose tumours were profiled for RNA (n = 96), feature S(1,−1)SumAverg was significantly associated with the expression of gene MOV10L1, LRP1B, ZFY, PITX2, TRAPPC12, MMGT1 and PPP2R2C (all P < 0.05; Fig. 2 and Supplementary Table S9).