Combined with the direct function of intracellular ANGPTL4, these results disclosed another parallel pathway of hypoxia-ANGPTL4-mediated radioresistance in NSCLC, suggesting that ANGPTL4 could be transported to bystander normoxic NSCLC through exosomes and subsequently inhibited the occurrence of ferroptosis and promoted the radioresistance of bystander cells. The gene discussed is ANGPTL4; the disease is non-small cell lung carcinoma.