These innovative findings on the relationships among ANGPTL4, ferroptosis, and hypoxia-induced radioresistance have unmasked the roles of intracellular ANGPTL4 and hypoxic exosomal ANGPTL4 in driving resistance to radiotherapy and revealed the potential of exploiting this intrinsic association to improve the clinical outcomes of NSCLC treatment. The gene discussed is ANGPTL4; the disease is non-small cell lung carcinoma.