Our study established a strong link between ferroptosis and hypoxia-induced radioresistance, which was derived from the findings that a robust induction of ferroptosis inhibition-related proteins of GPX4, SLC7A11, FTH1 and FTL under hypoxic NSCLC cells (Fig. 3a). The gene discussed is SLC7A11; the disease is non-small cell lung carcinoma.