With the low numbers of patients with CKD in our cohort, 17 patients totally, 12 septic and 5 non-septic patients, statistics are not feasible, but median level of hepcidin was 41.5 nmol/L among the septic patients with CKD whereas only 4.7 nmol/L in the non-septic patients, the latter inconsistent with what has been reported on CKD without sepsis59. Here, HAMP is linked to chronic kidney disease.