CD8A and cancer: The spatial neighboring of a complex immune cell programming contributes to cancer prognosis including other phenotypes of T cells (e.g., CD4: Treg cells, Th1, Th2, Th17, and Tfh; CD8: Stem-like, exhausted, memory, and cytotoxic T cells), B cells, different phenotypes of macrophages (M1, and M2), mast cell, neutrophils, among others5.