Further, myo-inositol is needed to synthesize phosphatidylinositol (PI) and PI-phosphates (PIP) which are essential signaling molecules in the PI3K-AKT-mTOR pathway, which serves as a major controller of both lipid anabolic and catabolic pathways in many tissues and this pathway is known to be disrupted in obesity as well as diabetes54–56. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.