MTOR and Obesity: Further, myo-inositol is needed to synthesize phosphatidylinositol (PI) and PI-phosphates (PIP) which are essential signaling molecules in the PI3K-AKT-mTOR pathway, which serves as a major controller of both lipid anabolic and catabolic pathways in many tissues and this pathway is known to be disrupted in obesity as well as diabetes54–56.