The hypothesis that GSK3β is inactive in CLL cells is supported by the evidence that several kinases which inhibit GSK3β activity by S9-phosphorylation [25, 26], as PI3K/AKT, PKA, PKC, p90RSK and p70S6K [22–27], are aberrantly activated by microenvironment in CLL [2, 45]. Here, RPS6KB1 is linked to B-cell chronic lymphocytic leukemia.