At support of this hypothesis, we found that in CLL cells stimulated for 15 min with 10 μg/ml anti-IgM/IgG antibodies, the increase in N1-ICD levels, induced by BCR stimulation, was prevented by pretreatment with 5 μM AKTiX for 6 h (n = 6; Supplementary Fig. S5). The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.