Even the combination of DT-061 with venetoclax could hold promise, considering that one of the mechanisms of resistance to venetoclax in CLL is represented by the high expression of Mcl-1 [65], and that DT-061 reduces the levels of both Mcl-1 and NOTCH1 signaling, which has been shown to sustain Mcl-1 expression in CLL cells [7]. Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.