JMJD5 is highly expressed in breast cancer cell lines, the knockdown of which resulted in tumor cell growth arrest.149 It was recently suggested that there is significantly lower mRNA expression of JMJD5 in breast cancer, hepatocellular carcinoma, and lung cancer, but a higher expression in stomach adenocarcinoma than in normal tissues. This evidence concerns the gene KDM8 and gastric adenocarcinoma.