KDM6B and cancer: Previous evidence also investigated the important yet poorly defined role of JMJD3 in the metastasis of CRC, the second most lethal cancer worldwide in 2020.2 The aberrant expression of Wnt/β-catenin pathway molecules is often observed in a wide spectrum of cancers and is believed to be associated with epigenetic modulation of key gene promoters in colon cancer.115 JMJD3 has a dual role in CRC as a tumor suppressor and tumor activator.