KDM8 and cancer: JMJD5 can either interacts with androgen receptor (AR) and modulates androgen response, or with PKM2 to regulate tumor metabolism under androgen-deprived conditions.165 Moreover, JMJD5 inhibition prevented cancer-stem-cell-like mediated by cancer upregulated gene 2 (CUG2).166 In pancreatic cancer however, JMJD5 negatively regulates c-Myc expression, which suppresses tumor cell proliferation and glycolytic metabolismr.167