KDM4A and acute myeloid leukemia: JMJD2 family members take active parts in multiple physiological processes, including cell proliferation, migration,51 gene transcription,52 and genome stability.53 In embryonic stem cells (ESCs), KDM4B and KDM4C interact with pluripotency factors such as Sox2, Oct4, c-Myc, and Klf4, thereby regulating cell proliferation and stem-cell features.54,55 It was recently reported that JMJD2A, B, and C were all crucial to the survival of acute myeloid leukemia cells,56 but the individual role of each member varied significantly.