It was found that JMJD3 might also directly interact with p53.108,109 The role of JMJD3 on cancer is highly controversial, with tumor inhibitory effects on CRC, hepatic cancer, pancreatic cancer, glioma and B-cell lymphoma, and tumor-promoting effect on cancers such as renal breast, prostate, and ovarian cancer. This evidence concerns the gene TP53 and cancer.