KDM4A and colorectal carcinoma: Under such circumstances, the expression of several hypoxia-inducible genes was upregulated by JMJD2B via demethylation of H3K9me on their promoters.99 It was recently suggested that Wnt-mediated CRC metastasis is partially dependent on JMJD2 to form an epigenetic complex that activates disintegrin and metalloproteinase (ADAM) transcription.100