The overexpression of JMJD3 is often observed in germinal center B (GC-B) cells in Hodgkin lymphoma (HL)138 and diffuse large B-cell lymphoma (DLBCL).139,140 Following JMJD3 blockade treatment, the H3K27me3 level on target genes was significantly decreased in HL, supporting the conclusion that JMJD3 is involved in the development of HL.138 In DLBCL, JMJD3 promotes the phosphorylation of proteins mediating the B-cell receptor (BCR) signaling. The gene discussed is KDM6B; the disease is Hodgkins lymphoma.