In lung cancer, JMJD2A decreased the transcription of tumor suppressor gene CHD5 to block cellular senescence, which ultimately stimulated cellular transformation.67 Likewise, the upregulation of JMJD2A expression was later reported in prostate cancer and bladder cancer tissues.68 In bladder cancer, JMJD2A promoted epithelial-mesenchymal transition (EMT) by modulating SLUG expression. The gene discussed is KDM4A; the disease is prostate cancer.