KDM4A and Familial prostate cancer: In lung cancer, JMJD2A decreased the transcription of tumor suppressor gene CHD5 to block cellular senescence, which ultimately stimulated cellular transformation.67 Likewise, the upregulation of JMJD2A expression was later reported in prostate cancer and bladder cancer tissues.68 In bladder cancer, JMJD2A promoted epithelial-mesenchymal transition (EMT) by modulating SLUG expression.