The impact of JMJD6 on transcriptional regulator Aire reflects its critical role in the spontaneous development of multi-organ autoimmunity in mice, such as thymus and T cell development.359 For example, in patients with chronic hepatitis B virus infection, T lymphocytes usually experience a decrease in JMJD6 expression.360 It is thus postulated that the “exhausted” T cells when exposed to chronic inflammation can be partially attributed to aberrant JMJD6 expression. This evidence concerns the gene JMJD6 and Autoimmunity.