For instance, in clear cell renal cell carcinoma (CCRCC), mutations in JARID1C gene lead to its functional loss and the preferential occurrence of CCRCC in males.269,270 JARID1C could impair the development of papilloma virus-related malignancies by forming a complex with viral E2 that suppressed the E6 and E7 viral oncoprotein promoters.271. Here, KDM5C is linked to nonpapillary renal cell carcinoma.