KDM4D and gastric cancer: JMJD2B is associated with invasion and metastasis of gastric cancer by inducing EMT.80 JMJD2B and β-catenin collectively promote the transcription of β-catenin target gene vimentin via H3K9 demethylation.80 The overexpression of JMJD2B was found to correlate with the abundance of p-c-Jun in gastric cancer, which is predictive of poor survival.81 In classical Hodgkin lymphoma, the elevated expression of JMJD2B and JMJD2D was also associated with aggressive subtypes and suboptimal treatment response to radiation.82