JMJD2A promoted cell growth of colon cancer by increasing cell proliferation and at the same inhibiting apoptosis.58 JMJD2B is also overexpressed in CRC tissues, the inhibition of which promotes cell apoptosis providing a potential therapeutic strategy.98 JMJD2B could be induced under a hypoxic environment in a HIF-1α-dependent manner in CRC cells. This evidence concerns the gene KDM4A and malignant colon neoplasm.