KDM6A and cancer: The JMJD3 gene is located on chromosome 17p13.1101,102 and 88% homologous to the gene histone demethylase gene UTX (ubiquitously repeat transcribed tetratricopeptide repeat on the X chromosome).103 UTX was the first identified mutated histone demethylase gene associated with cancer104 and can remove the methyl groups from di-trimethylated H3K27.103,105–107 The location of JMJD3 is adjacent to p53 as well, a tumor suppressor, the mutation of which is a frequent event in cancer.