One of its target genes by its arginine demethylase activity is tumor necrosis factor receptor-associated factor 6 (TRAF6), which can be both methylated and demethylated at different arginine sites.181 TRAF6 could be involved in the pathogenesis of a variety of autoimmune diseases,356 and the reversible arginine methylation status of TRAF6 by JMJD6 thus provides a novel mechanism for regulation of innate immune pathways. The gene discussed is TRAF6; the disease is autoimmune disease.