IDH3A and non-small cell lung carcinoma: A subsequent study on non-small cell lung cancer (NSCLC) confirmed that histone Kla downregulated the gene expression of the glycolysis-related enzymes hexokinase (HK)-1 and pyruvate kinase (PKM) and upregulated that of the TCA cycle-related enzymes succinate dehydrogenase (SDH) and isocitrate dehydrogenase (IDH)90.