A subsequent study on non-small cell lung cancer (NSCLC) confirmed that histone Kla downregulated the gene expression of the glycolysis-related enzymes hexokinase (HK)-1 and pyruvate kinase (PKM) and upregulated that of the TCA cycle-related enzymes succinate dehydrogenase (SDH) and isocitrate dehydrogenase (IDH)90. The gene discussed is HK1; the disease is non-small cell lung carcinoma.