Additionally, studies have shown that LDH-A is overexpressed in all CD8+ T-cell subsets in the context of rheumatoid arthritis, and LDH-A inhibition can alleviate the inflammatory and destructive effects of CD8+ T cells in the development of autoimmune diseases144; to some extent, these findings may provide indirect evidence that lactic acid promotes chronic inflammation. This evidence concerns the gene CD8A and rheumatoid arthritis.