IL1B and asthma: Our study provides experimental evidence for the role of IL-1β in skin sensitization and the atopic march: first, the supplement of IL-1β exacerbates e.c. HDM-sensitization (where endogenous IL-1β level is low) and the subsequent asthma, thus somehow mimicking the effects of d.c. HDM sensitization; second, the depletion of IL-1β-expressing Gr-1hi or Gr-1hi+int cells reduces the d.c. HDM-triggered asthma, which is restored by the skin administration of IL-1β.