IL1B and asthma: Given the recognized role of airway neutrophils in persistent and severe asthma associated with corticosteroid-resistance54, it will be interesting to further investigate in mice whether allergic asthma developed following d.c. sensitization is more resistant to corticosteroid, and to explore in patients the possible link of skin IL-1β in AD lesions with the development of corticosteroid-resistant asthma with neutrophilic inflammation.