IL1B and allergic disease: In agreement with our data, the role of IL-1β on Th2 response has been also reported in several studies of allergy mouse models, where lung inflammation and/or Th2 cytokines are decreased in Il1b−/− mice sensitized by i.p. OVA/alum and i.n. challenged by OVA45, or exacerbated in mice co-treated with IL-1β with i.n. OVA46,47.