PDC and Stroke: In this study, we used common genetic variants, lying within or near the EGLN genes, to partially mimic PHD inhibition and assess the associated risk of cardiovascular disease [CVD: defined here as coronary artery disease (CAD), MI and stroke] with lifelong exposure to circulating Hgb level elevations through genetically proxied therapeutic PHD inhibition or other potential effects of targeting the EGLN genes.