This includes the NME family of likely histidine kinases [47,48], as well as the protein histidine phosphatase LHPP which has multifaceted activity as a tumour suppressor for a range of cancers [12,14], and the histidine phosphatase PHPT1, which is an oncogene involved in lung cancer [49]. This evidence concerns the gene PHPT1 and neoplasm.