In addition to apolipoprotein E, there were 27 additional proteins whose levels varied according to low versus high polygenic score for Alzheimer’s disease at a Bonferroni corrected p-value 1.5 x 10−5 (0.05/ 3231; Fig 3A and 3C and S3 Table). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.