MAPT and tauopathy: Moreover, Hsp27 can effectively inhibit the amyloid aggregation of unphosphorylated Tau in vitro (Baughman et al., 2018; Baughman et al., 2020; Freilich et al., 2018), prevent cellular toxicity of Tau in SH-SY5Y cells (Choi et al., 2015), and rescue tauopathies in Tau transgenic mice (Abisambra et al., 2010).