To investigate the influence of Hsp27 on the abnormal aggregation of pTau and its neuropathology in vivo, we used a Drosophila tauopathy model where human pathogenic mutant Tau (TauR406W), associated with FTD with parkinsonism linked to chromosome 17 (FTDP-17), is expressed in the nervous system by a pan-neuronal driver elavC155-GAL4. This evidence concerns the gene LGALS4 and frontotemporal dementia.