MAPT and early-onset autosomal dominant Alzheimer disease: Pathological aggregation and propagation of microtubule-associated protein Tau is closely associated with Alzheimer’s disease (AD), frontotemporal dementia (FTD), and other tauopathies (Avila, 2006; Hanger et al., 2009; Hanger et al., 1998; Hanger et al., 1991; Spillantini and Goedert, 2013).