Over 58 different phosphorylation sites including MARK2-phosphorylation sites were identified on Tau40 in AD brains (Hanger et al., 1998; Hanger et al., 2007; Hasegawa et al., 1992; Morishima-Kawashima et al., 1995; Wesseling et al., 2020; Xia et al., 2021). This evidence concerns the gene MAPT and Alzheimer disease.