APCDD1 and neoplasm: However, no change in p27Kip1 expression was observed in PanNET tissue from hTS/Men1+/ΔN3-8 mice when compared with control Men1+/ΔN3-8 tumor tissue (mean staining score = 200 for both hTS/Men1+/ΔN3-8 and Men1+/ΔN3-8 mouse tissue) (Figure 5C).