APCDD1 and neuroendocrine neoplasm: Our observation that high TS levels shortened survival of hTS/Men1–/– and hTS/Men1+/– mice extends our previous work showing that TS expression in patients with TS-positive gastroenteropancreatic neuroendocrine tumors had worse outcome in comparison with patients with negligible TS expression as determined by univariate and multivariate survival analysis (15).