APCDD1 and adenoma: Since Men1+/ΔN3-8 mice did not develop carcinoma when tested up to 21 months of age (Figure 3C), we asked whether loss of heterozygosity (LOH) occurs in Men1+/ΔN3-8 mice that develop adenoma as well as in hTS/Men1+/ΔN3-8 mice that develop carcinoma by 9 months of age.