Our observation that high TS levels shortened survival of hTS/Men1–/– and hTS/Men1+/– mice extends our previous work showing that TS expression in patients with TS-positive gastroenteropancreatic neuroendocrine tumors had worse outcome in comparison with patients with negligible TS expression as determined by univariate and multivariate survival analysis (15). This evidence concerns the gene MEN1 and neuroendocrine neoplasm.