We found a 4-fold increase in Ki-67 index in adenoma isolated from hTS/Men1–/– mice compared with adenoma from Men1–/– mice (P = 0.0006) and a 3.2-fold increase of Ki-67 index in carcinoma isolated from hTS/Men1–/– mice when compared with carcinoma from Men1–/– mice (P = 0.024) (Figure 4A). This evidence concerns the gene APCDD1 and carcinoma.