FBLN2 and central nervous system cancer: Although the discrepancy between the observed fibulin-2 overexpression in our model and the expression levels in human gliomas warrants for further investigation, it is interesting to note that we observed a reduction of fibulin-2 protein expression at 21D time points as compared to 7D and 14D, and this finding is consistent with fibulin-2 reduced protein levels in high-grade gliomas as compared to low-grade gliomas in humans [9].