CD8A and myeloid sarcoma: B lymphocytes play an important role in MS pathology in the context of both relapsing and progressive MS [24–26], promoting injury through direct activation of lymphocytes (CD8 cytotoxic T lymphocytes) [26–29], and other neuro-inflammatory cells (e.g., macrophages, microglia, astrocytes) [30, 31] or the production of pro-inflammatory cytokines [32].