Several clinical trials demonstrated that a potent CREB activator forskolin could be beneficial for asthma, obesity, and inflammatory diseases treatment.[22, 23, 24] To explore whether forskolin could aid IVDD progression by activating CREB signaling, we microinjected forskolin to NP site to induce enhancement of CREB signaling (Figure8A). Here, CREB1 is linked to obesity due to melanocortin 4 receptor deficiency.