Mice IVDD model was created by AF puncture (AFP) as previously reported.[25] SOFG staining and magnetic resonance imaging (MRI) test showed AFP could significantly induce IVDD phenotype 4 weeks after the procedure, and this IVDD phenotype was significantly attenuated by forskolin treatment (Figure 8B,C; Figure S7A,B, Supporting Information), and this finding was in accordance with another line of evidence which revealed that RAMP1 overexpression in IVD alleviated AFP‐induced IVDD (Figure S8, Supporting Information), suggesting activation of RAMP1/CREB signaling ameliorates IVDD progression. This evidence concerns the gene AFP and atrial fibrillation.