Patients with PE/PAH had more CD8+ Temra cells expressing homing receptor ZNF683 transcripts (cluster 5) throughout the treatment (P < 0.0001, Fisher’s 2-sided test) and fewer IFNG-producing CD8+ Temra cells (cluster 9) than patients without PE/PAH (Figure 6C and Supplemental Table 3). Here, CD8A is linked to pulmonary arterial hypertension.