ERBB2 and gastric cancer: Currently, T-DXd is being evaluated in a phase II trial in patients with HER2-positive gastric cancer in an earlier line of therapy i.e., progressed on or after trastuzumab treatment (phase II DESTINY-Gastric02, NCT04014075) as well as in combination with chemotherapy, immunotherapy and trastuzumab (phase Ib/II DESTINY-Gastric03, NCT04379596).