BAX and glioblastoma: Among natural Bax variants found in tumors, an N-terminally truncated mutant called BaxΨ was found in low-grade glioblastoma [131], and this variant was found to be more active than full-length Bax in mammalian cells, in yeast, and in reconstituted systems, leading to the conclusion that the N-terminal end of Bax was a negative regulator of its activity [132, 133].