In addition, because the high levels of neuroinflammatory response (Zass et al., 2017) and impairment of CREB-BDNF signaling (Ji et al., 2017) and hippocampal neurogenesis (Besnard and Sahay, 2016) have been shown to be closely related to the pathogenesis of PTSD, researchers should clarify whether the anti-PTSD effect of paeoniflorin could be mediated by its inhibitory effect on neuroinflammation and its ameliorative effect on CREB-BDNF signaling and hippocampal neurogenesis. This evidence concerns the gene CREB1 and post-traumatic stress disorder.