CDC42BPA and cancer: Regarding cancer cell migration and invasion, these two processes depending on cell-cell and cell-extracellular matrix adhesion, require the contractility of the cytoskeletal actomyosin, regulated by Rho-associated protein kinase (ROCK) and myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) activation, and the production and secretion of matrix metalloproteinases, enzymes degrading the extracellular and basement membrane proteins (Lawson and Ridley, 2018).