Furthermore, the phospholipase C gamma 2 (PLCG2)/inositol 1,4,5-trisphosphate (IP3)/Ca2þ/protein kinase C (PKC) pathway regulated the activation of macropinocytosis and promoted chRCC cell proliferation under nutrient stress (Xiao et al., 2020). Here, PLCG2 is linked to chromophobe renal cell carcinoma.