Moreover, in the retina, hyperglycemia-associated diabetes leads to the generation of diacylglycerol (DAG) that activates protein kinase C (PKC), especially the beta isoform, which is involved in the positive control of VEGF expression (Amadio et al., 2010; Geraldes and King, 2010). The gene discussed is VEGFA; the disease is Hyperglycemia.