Microbes and their products can activate the major inflammation-activated transcription factor NF-κB; then, by inducing the production of IL-6, TNF, and other cytokines, NF-κB can accelerate the development of colon (Greten et al., 2004; De Santis et al., 2015) and pancreatic (Zhang et al., 2013) cancers. The gene discussed is NFKB1; the disease is cancer.