Through reanalysis of the GSE4745, we identified the black module as the most significant for diabetic HF with WGCNA and CIBERSORT algorithms, then identified five hub genes based on their degree values from the PPI network.: PSMB8, NFKB1, ALB, EDN1, and ESR1. Proteasome subunit beta 8) is a catalytic subunit involved in tumor infiltration and neuroinflammation (21, 22). Here, ESR1 is linked to neoplasm.