SAB induced apoptosis and inhibited tumor cells angiogenesis by inhibiting expression of Cox-2, HGF, MMP-2, HIF-1α, TNFα, MMP-9, tenascin, osteopontin as well as transforming growth factor (TGF)-1β and up-regulating the level of THBS-2 [75]. The gene discussed is HIF1A; the disease is neoplasm.