PF4 and non-small cell lung carcinoma: In NSCLC, tumor-derived platelet factor 4 [PF4, chemokine (C-X-C motif ) ligand 4 (CXCL4)] [65] has been reported to promote megacarbonite-mediated platelet production in the bone marrow and an RNA panel was altered in TEPs in metastatic NSCLC patients [66].