MAPT and Alzheimer disease: The main pathological features of AD consist of amyloid plaques formed by abnormal aggregation of Aβ in the brain and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein in neuronal cells [16, 17], which is associated with a range of neurodegenerative events involving microglia cell activation, neurite dystrophy, neuroinflammation, oxidative injury, and mitochondrial disorder [17–19].