They found that MG1363-PMG36E -GLP-1 reduced neuroinflammation by downregulating the TLR4/NF-κB signaling, upregulated the AKT/GSK3β pathway, and restored the disturbed microbiome to normality, remarkably alleviating spatial learning and memory impairment in AD mice [159]. The gene discussed is NFKB1; the disease is Alzheimer disease.