Moreover, as a result of pre-incubation of cells with an NCX inhibitor KB-R7943, the inhibitor showed a blunted effect on [Ca2+]i, and significantly augmented the cisplatin-induced cell death of cisplatin resistant ovary carcinoma cells without effecting cisplatin-induced cell death of cisplatin sensitive ovary carcinoma cells. This evidence concerns the gene TLX2 and ovarian carcinoma.