Another in vitro study has reported that in addition to inducing ROS mediated cytotoxicity in lung cancer cells, PL modulated the expressions of the Sp regulated genes such as cyclin D1, EGFR, hepatocyte growth factor receptor (HGFR), and survivin and also suppressed the transcription factors Sp1, Sp3, and Sp4 [125]. The gene discussed is MET; the disease is lung cancer.