PL was found to significantly inhibit the activation of NF-κB and modulate the expressions of NF-κB mediated proteins such as IL-6, IL-8, MMP-9, and intercellular adhesion molecule 1 (ICAM-1), thereby suppressing the metastatic potential of the prostate cancer cells [101]. This evidence concerns the gene NFKB1 and Familial prostate cancer.