NANOG and cancer: Thus, it is evident that when used in combination with PL, very low intensity of radiation is found to be effective in cancer cells which is extremely important because radiation therapy is associated with numerous side effects such as mutation, alopecia, myelosuppression, etc. Further, PL attenuated the mRNA levels of the cancer stem cells associated markers such as SOX2, NANOG, and Oct-4, ultimately inhibiting cancer stem cell properties which is one of the major obstacles to radiation therapy [144].