Furthermore, PL suppressed NF-κB activation, and other NF-κB regulated genes including c-myc, cyclin D1, Bcl-2, Bcl-xL, survivin, XIAP, VEGF, and MMP-9 in pre-clinical models of pancreatic cancer, which led to suppression of cell proliferation and induction apoptosis [115]. Here, NFKB1 is linked to familial pancreatic carcinoma.