NSD2 and Wolf-Hirschhorn syndrome: For example, the t(4;14), present in 15% of MM [90, 91], leads to increased expression of the Wolf-Hirschhorn syndrome candidate gene (WHSC1, also known as MMSET and now NSD2) and the receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) gene [92, 93].