While H. pylori bacteria are dominated in the stomach, their lipopolysaccharide (LPS) and surface proteins are released in the gastric lamina propria, after which they might provoke macrophages to increase the expression of pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-8, IL-17, tumor necrosis factors-α (TNF-α), and ultimately increases the risk of developing H. pylori-induced gastric carcinoma (Naito and Yoshikawa, 2002; Fehlings et al., 2012; Guo et al., 2013). The gene discussed is TNF; the disease is gastric carcinoma.