CD4 and cholesteryl ester measurement: In addition, the increase in the number of CD4+ T cells was larger than that of CD8+ T cells in the pericyst areas in the CLT specimens from CE patients (33.7% for CD4+ T cells vs. 11.5% for CD8+ T cells) (Figure 2C), suggesting that a predominantly CD4+ T-cell-mediated immune response was critical in the liver of persistent CE patients.