In addition to that, administration of extracts of Withaferin A and Withania somnifera have suppressed the inflammatory cytokines such as IL-1β, IL-6, and TNF-α and modulated many inflammatory pathways including NLRP3 inflammasome, NF-κB pathway, and infection-induced TLR4 expression in macrophages through chaperone activity of peroxiredoxins as interventions of inflammatory response in different studies models (Noh et al., 2016; Khan et al., 2018; Wang et al., 2020b; Balkrishna et al., 2020; Aziz et al., 2020). This evidence concerns the gene TLR4 and infection.