In parasites, Toxoplasma and Cryptosporidium share the similar subtilisin SUB1, which acts as a pioneer for the parasite’s infection (Wanyiri et al., 2009; Saouros et al., 2012), while Plasmodium falciparum SUB1 processes membrane-anchored protein MSP1, which interacts with Red Blood Cell spectrin cytoskeleton, playing a role in the egress of merozoite from erythrocytes (Das et al., 2015). Here, SUB1 is linked to infection.