While the human Ahnak gene was initially cloned from tumor cells (Shtivelman and Bishop, 1993) and later characterized as a tumor suppressor (Lee et al., 2014), chemotherapy-induced p11/AnxA2/Supt6h complex is known to facilitate Oct4-mediated gene transcription and thereby is involved in chemotherapy-induced breast cancer stem cell enrichment (Lu et al., 2020). This evidence concerns the gene ANXA2 and neoplasm.