Finally, alterations of p11 or its binding partners are implicated in pathobiologies relevant to other diseases, including Parkinson’s disease (Zhang et al., 2008; Marongiu et al., 2016; Schintu et al., 2016; Green et al., 2017), drugs of abuse (Arango-Lievano et al., 2014; Thanos et al., 2016), and various cancers (Lokman et al., 2011; Lee et al., 2014; Noye et al., 2018; Bharadwaj et al., 2020; Lu et al., 2020), in which depression is a common comorbid condition. This evidence concerns the gene S100A10 and depressive disorder.